Structure-based glycoengineering of interferon lambda 4 enhances its productivity and anti-viral potency
نویسندگان
چکیده
منابع مشابه
Interferon Lambda Genetics and Biology in Regulation of Viral Control
Type III interferons, also known as interferon lambdas (IFNλs), are the most recent addition to the IFN family following their discovery in 2003. Initially, IFNλ was demonstrated to induce expression of interferon-stimulated genes and exert antiviral properties in a similar manner to type I IFNs. However, while IFNλ has been described to have largely overlapping expression and function with typ...
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Interferon-lambda (IFN-λ) is a recently described cytokine found to be of critical importance in innate immune regulation of intestinal viruses. Endogenous IFN-λ has potent antiviral effects and has been shown to control multiple intestinal viruses and may represent a factor that contributes to human variability in response to infection. Importantly, recombinant IFN-λ has therapeutic potential ...
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Interferon (IFN) lambdas are critical antiviral effectors in hepatic and mucosal infections. Although IFNλ1, IFNλ2, and IFNλ3 act antiviral, genetic association studies have shown that expression of the recently discovered IFNL4 is detrimental to hepatitis C virus (HCV) infection through a yet unknown mechanism. Intriguingly, human IFNL4 harbors a genetic variant that introduces a premature sto...
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Toll-like receptors (TLRs) recognize specific microbial products in the innate immune response. TLR3, a double-stranded RNA sensor, is thought to have an important role in viral infections, but the regulation of TLR3 expression and its function in keratinocytes are not fully understood. Here we show the Th1 cytokine IFN-γ increased the TLR3 expression via STAT1 in cultured normal human epiderma...
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Generalized Lambda Distribution is an extension of Tukey's lambda distribution, that is very flexible in modeling information and statistical data. In this paper, We introduced two parameterization of this distribution. Then We estimate parameters by moment matching, percentile, starship and maximum likelihood methods and compare two parameterization and parameter estimation method...
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ژورنال
عنوان ژورنال: Cytokine
سال: 2020
ISSN: 1043-4666
DOI: 10.1016/j.cyto.2019.154833